A great CityPaper article (which you can read here: http://www.washingtoncitypaper.com/bestofdc/artsandentertainment/2009/best-obama-mural-on-the-outside-of-a-restaurant ) chronicles the history of this piece: Mama Ayesha's is a family run biz and when they originally conceived of the mural they wanted on the side of their restaurant, they wanted to honor a regular at the restaurant, Helen Thomas. "'She was going to be in a chair, with pen and paper,' the restaurant’s co-owner Mohammed Abu-El-Hawa, Mama Ayesha’s great-nephew" told the City Paper's Jule Banville. "But Thomas, he says, 'is very modest and didn’t want all the attention.' She applauded the suggestion of replacing her image with Mama’s as a tribute." The rest is history.
Located over the parking lot of Mama Ayesha's restaurant, facing Duke Ellington Bridge.